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Autism and genius: is there a link? The involvement of central brain loops and hypotheses for functional testing - ProQuest
Type Page Web URL http://search.proquest.com/openview/a3f42157410e9f8bb957a05744b2c932/1?pq-origsite=gscholar Consulté le 22/05/2016 à 23:05:59 Titre abrégé Autism and genius Date d'ajout 22/05/2016 à 23:05:59 Modifié le 22/05/2016 à 23:05:59 Pièces jointes
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Autism Genes Linked to Higher Intelligence
Type Page Web URL http://www.medscape.com/viewarticle/841615 Consulté le 16/05/2016 à 00:07:31 Date d'ajout 16/05/2016 à 00:07:31 Modifié le 16/05/2016 à 00:07:31 Marqueurs :
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Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population
Type Article de revue Auteur T.-K. Clarke Auteur M. K. Lupton Auteur A. M. Fernandez-Pujals Auteur J. Starr Auteur G. Davies Auteur S. Cox Auteur A. Pattie Auteur D. C. Liewald Auteur L. S. Hall Auteur D. J. MacIntyre Auteur B. H. Smith Auteur L. J. Hocking Auteur S. Padmanabhan Auteur P. A. Thomson Auteur C. Hayward Auteur N. K. Hansell Auteur G. W. Montgomery Auteur S. E. Medland Auteur N. G. Martin Auteur M. J. Wright Auteur D. J. Porteous Auteur I. J. Deary Auteur A. M. McIntosh URL http://www.nature.com/mp/journal/v21/n3/full/mp201512a.html Autorisations © 2015 Nature Publishing Group Volume 21 Numéro 3 Pages 419-425 Publication Molecular Psychiatry ISSN 1359-4184 Date mars 2016 Abrév. de revue Mol Psychiatry DOI 10.1038/mp.2015.12 Consulté le 09/05/2016 à 01:32:43 Catalogue de bibl. www.nature.com Langue en Résumé Cognitive impairment is common among individuals diagnosed with autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). It has been suggested that some aspects of intelligence are preserved or even superior in people with ASD compared with controls, but consistent evidence is lacking. Few studies have examined the genetic overlap between cognitive ability and ASD/ADHD. The aim of this study was to examine the polygenic overlap between ASD/ADHD and cognitive ability in individuals from the general population. Polygenic risk for ADHD and ASD was calculated from genome-wide association studies of ASD and ADHD conducted by the Psychiatric Genetics Consortium. Risk scores were created in three independent cohorts: Generation Scotland Scottish Family Health Study (GS:SFHS) (n=9863), the Lothian Birth Cohorts 1936 and 1921 (n=1522), and the Brisbane Adolescent Twin Sample (BATS) (n=921). We report that polygenic risk for ASD is positively correlated with general cognitive ability (beta=0.07, P=6 × 10−7, r2=0.003), logical memory and verbal intelligence in GS:SFHS. This was replicated in BATS as a positive association with full-scale intelligent quotient (IQ) (beta=0.07, P=0.03, r2=0.005). We did not find consistent evidence that polygenic risk for ADHD was associated with cognitive function; however, a negative correlation with IQ at age 11 years (beta=−0.08, Z=−3.3, P=0.001) was observed in the Lothian Birth Cohorts. These findings are in individuals from the general population, suggesting that the relationship between genetic risk for ASD and intelligence is partly independent of clinical state. These data suggest that common genetic variation relevant for ASD influences general cognitive ability. Date d'ajout 09/05/2016 à 01:32:43 Modifié le 09/05/2016 à 01:32:43 Marqueurs :
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Genome-wide association studies establish that human intelligence is highly heritable and polygenic
Type Article de revue Auteur G. Davies Auteur A. Tenesa Auteur A. Payton Auteur J. Yang Auteur S. E. Harris Auteur D. Liewald Auteur X. Ke Auteur S. Le Hellard Auteur A. Christoforou Auteur M. Luciano Auteur K. McGhee Auteur L. Lopez Auteur A. J. Gow Auteur J. Corley Auteur P. Redmond Auteur H. C. Fox Auteur P. Haggarty Auteur L. J. Whalley Auteur G. McNeill Auteur M. E. Goddard Auteur T. Espeseth Auteur A. J. Lundervold Auteur I. Reinvang Auteur A. Pickles Auteur V. M. Steen Auteur W. Ollier Auteur D. J. Porteous Auteur M. Horan Auteur J. M. Starr Auteur N. Pendleton Auteur P. M. Visscher Auteur I. J. Deary URL http://www.nature.com/mp/journal/v16/n10/full/mp201185a.html Autorisations © 2011 Nature Publishing Group Volume 16 Numéro 10 Pages 996-1005 Publication Molecular Psychiatry ISSN 1359-4184 Date octobre 2011 Abrév. de revue Mol Psychiatry DOI 10.1038/mp.2011.85 Consulté le 22/05/2016 à 23:34:59 Catalogue de bibl. www.nature.com Langue en Résumé General intelligence is an important human quantitative trait that accounts for much of the variation in diverse cognitive abilities. Individual differences in intelligence are strongly associated with many important life outcomes, including educational and occupational attainments, income, health and lifespan. Data from twin and family studies are consistent with a high heritability of intelligence, but this inference has been controversial. We conducted a genome-wide analysis of 3511 unrelated adults with data on 549 692 single nucleotide polymorphisms (SNPs) and detailed phenotypes on cognitive traits. We estimate that 40% of the variation in crystallized-type intelligence and 51% of the variation in fluid-type intelligence between individuals is accounted for by linkage disequilibrium between genotyped common SNP markers and unknown causal variants. These estimates provide lower bounds for the narrow-sense heritability of the traits. We partitioned genetic variation on individual chromosomes and found that, on average, longer chromosomes explain more variation. Finally, using just SNP data we predicted ~1% of the variance of crystallized and fluid cognitive phenotypes in an independent sample (P=0.009 and 0.028, respectively). Our results unequivocally confirm that a substantial proportion of individual differences in human intelligence is due to genetic variation, and are consistent with many genes of small effects underlying the additive genetic influences on intelligence. Date d'ajout 22/05/2016 à 23:34:59 Modifié le 22/05/2016 à 23:34:59 Marqueurs :
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L’intelligence émotionnelle – trait chez les adolescents à haut potentiel : spécificités et liens avec la réussite scolaire et les compétences sociales
Type Article de revue Auteur Sophie Brasseur Auteur Jacques Gregoire URL http://www.necplus.eu/abstract_S0013754510001060 Volume 2010 Numéro 01 Pages 59 Publication Enfance ISSN 0013-7545, 1969-6981 Date 3/2010 DOI 10.4074/S0013754510001060 Consulté le 11/05/2016 à 22:24:39 Catalogue de bibl. CrossRef Langue en Titre abrégé L’intelligence émotionnelle – trait chez les adolescents à haut potentiel Date d'ajout 11/05/2016 à 22:24:39 Modifié le 11/05/2016 à 22:24:39 Marqueurs :
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Molecular Genetic Evidence for Shared Etiology of Autism and Prodigy
Type Article de revue Auteur Joanne Ruthsatz Auteur Stephen A. Petrill Auteur Ning Li Auteur Samuel L. Wolock Auteur Christopher W. Bartlett Volume 79 Numéro 2 Pages 53-59 Publication Human Heredity ISSN 1423-0062 Date 2015 Extra PMID: 25791271 Abrév. de revue Hum. Hered. DOI 10.1159/000373890 Catalogue de bibl. PubMed Langue eng Résumé Child prodigies are rare individuals with an exceptional working memory and unique attentional skills that may facilitate the attainment of professional skill levels at an age well before what is observed in the general population. Some characteristics of prodigy have been observed to be quantitatively similar to those observed in autism spectrum disorder (ASD), suggesting possible shared etiology, though objectively validated prodigies are so rare that evidence has been sparse. We performed a family-based genome-wide linkage analysis on 5 nuclear and extended families to search for genetic loci that influence the presence of both prodigy and ASD, assuming that the two traits have the same genetic etiology in the analysis model in order to find shared loci. A shared locus on chromosome 1p31-q21 reached genome-wide significance with two extended family-based linkage methods consisting of the Bayesian PPL method and the LOD score maximized over the trait parameters (i.e., MOD), yielding a simulation-based empirical significance of p = 0.000742 and p = 0.000133, respectively. Within linkage regions, we performed association analysis and assessed if copy number variants could account for the linkage signal. No evidence of specificity for either the prodigy or the ASD trait was observed. This finding suggests that a locus on chromosome 1 increases the likelihood of both prodigy and autism in these families. Date d'ajout 22/05/2016 à 23:13:05 Modifié le 22/05/2016 à 23:13:05 Marqueurs :
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The beautiful otherness of the autistic mind
Type Article de revue Auteur Francesca Happé Auteur Uta Frith URL http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677594/ Volume 364 Numéro 1522 Pages 1345-1350 Publication Philosophical Transactions of the Royal Society B: Biological Sciences ISSN 0962-8436 Date 2009-5-27 Extra PMID: 19528016 PMCID: PMC2677594 Abrév. de revue Philos Trans R Soc Lond B Biol Sci DOI 10.1098/rstb.2009.0009 Consulté le 16/05/2016 à 00:08:40 Catalogue de bibl. PubMed Central Date d'ajout 16/05/2016 à 00:08:40 Modifié le 16/05/2016 à 00:08:40 Marqueurs :
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mardi 24 mai 2016
Bibliographie - Lien génétiques entre traits autistiques et QI, et sociobiologie de la neurodiversité
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